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P3‐138: Prevalence of sleep disorders in an MCI population and association with cognitive subtypes
Author(s) -
Bombois Stéphanie,
Delbeuck Xavier,
Laurier Laurence,
Jecquesson JeanMarie,
Derambure Philippe,
Monaca Christelle,
Pasquier Florence
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1113
Subject(s) - epworth sleepiness scale , dementia , polysomnography , medicine , effects of sleep deprivation on cognitive performance , neuropsychology , population , memory clinic , body mass index , cognition , cognitive decline , physical therapy , audiology , psychology , psychiatry , apnea , disease , environmental health
Background: Patients with mild cognitive impairment (MCI) are at high risk to progress to dementia. Some sleep disorders are associated with cognitive deficit, and have been reported as predictive factors for dementia.The aim of the study is to determine the prevalence of sleep disorders in MCI patients attending a memory clinic, and to test the association between sleep features and cognitive profile. Methods: Consecutive patients with MCI (cognitive complain, normal general cognitive functioning, objective impairment in at least one cognitive domain as evident by scores < 1.5 SD below the age appropriate mean, preserved activities of the daily living, and no dementia) were included. A standardized clinical, neuropsychological and sleep evaluation with a polysomnography during 2 consecutive nights were performed. MCI cognitive profiles were classified as amnestic single or multiple domains and non amnestic single or multiple domains. Results: We included 65 MCI patients (mean age 67.7 6 6.7 years; 50.8% women). Arterial hypertension was present in 47.7% of the patients, dyslipidemia in 55.4%, diabetes in 20%, and cardiopathy in 20%. The mean body mass index was 25.6 6 3.7. The mean MMSE was 28.1 6 2.0 points. Ten patients (15.4%) had an amnestic single domain MCI subtype, 26 (40%) an amnestic multiple domains, 19 (29.2%) a non amnestic single domain, and 10 (15.4%) a non amnestic multiple domains. The total sleep time was 404.7 6 75.3 min, mean apopnea/hypopnea index was 15.8 6 12.2. The mean Epworth Sleepiness Scale was 7.2 6 4.4. An obstructive sleep apnea was diagnosed in 84.6% of the MCI patients, a restless legs syndrome in 30.8%, and periodic limb movements in 36.9%. One patient had rapid eye movement sleep disorders. In a statistical multivariate model, sleep disorders and polysomnographic data were not associated with any MCI cognitive subtypes. Conclusions: Sleep disorders are highly prevalent in our cohort of MCI patients, whatever the cognitive subtype. The follow-up of these patients will document the influence of the treatment of sleep disorders on cognition.