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P3‐124: Classification models for early identification of persons at risk for dementia
Author(s) -
Van Den Kommer Tessa N.,
Bontempo Daniel E.,
Comijs Hannie C.,
Hofer Scott M.,
Dik Miranda G.,
Piccinin Andrea M.,
Jonker Cees,
Deeg Dorly J.H.,
Johansson Boo
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1099
Subject(s) - dementia , medicine , predictive value , psychiatry , disease
shared dementia risk) husband’s education and occupation. Results: Incident dementia was diagnosed in 255 subjects (221 of whom had dementia-free spouse and 34 of whom had spouse with incident dementia) . In an age-stratified model with all covariates included, a subject whose spouse experienced incident dementia onset had a six-fold (HR1⁄46.01, 95% CI: 2.23-16.17, p1⁄4.0004) increase in the hazard for incident dementia in relation to subjects whose spouses were dementia free, with equivalent findings for men and women. Few subjects (0 men, 4 women) with spouses without dementia became widowed, both precluding the ability and obviating the need to adjust for the potential confounding effects of widowhood. Conclusions: These results suggest that dementia caregiving increases dementia risk in spouse caregivers, net of the effect of key factors associated with dementia risk and socioeconomic status shared by both spouses. Future work will examine the effects of the rapidity of clinical course in spouse’s dementia and ameliorating effects of caregiver stress, personality and coping strategies, to inform potential caregiver interventions.