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P3‐105: Cognitive function of patients with partial anterior circulation infarct and amnestic mild cognitive impairment
Author(s) -
Zhang MeiYan,
Yang Qiong,
Yu Xin,
Liu Na,
Fan Dongsheng,
Wang Huali
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1080
Subject(s) - cognition , verbal fluency test , fluency , cognitive impairment , medicine , audiology , psychology , neuropsychology , psychiatry , mathematics education
180 AD patients, 59 MCI patients and 89 persons with subjective complaints who visited the Memory Clinic of the VU University Medical Center between 2004 and 2007 completed the S-IQCODE-N. Diagnoses were made independently of the S-IQCODE-N. Logistic regression and receiver operating characteristic (ROC) curves were used to evaluate the diagnostic ability. The dimensions of the questionnaire were investigated using exploratory and confirmatory factor analysis. Results: The S-IQCODE-N was able to differentiate AD from MCI or subjective complaints, but was not able to differentiate subjective complaints from MCI. A two factor model with memory versus IADL items provided a better fit than the one factor model. All subgroups differed from each other on the memory factor. For the IADL factor, no differences were found between MCI patients and people with subjective complaints, but both groups differed from AD patients. Conclusions: The S-IQCODE-N is useful in diagnosing AD, but of limited use in distinguishing between subjective complaints and MCI. Informant questionnaires with more complex IADL items might be able to discriminate between these relevant groups.