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P3‐248: Intravenous immunoglobulin (IVIg) Gammagard liquid contains anti‐RAGE IgG and sLRP
Author(s) -
Weber Alfred,
Engelmaier Andrea,
Teschner Wolfgang,
Ehrlich Hartmut J.,
Schwarz Hans Peter
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1021
Subject(s) - rage (emotion) , antibody , chemistry , receptor , recombinant dna , amyloid precursor protein , glycation , biochemistry , peptide , microbiology and biotechnology , biology , immunology , alzheimer's disease , medicine , gene , disease , neuroscience
rom arge poo s o uman p asma onat ons, as een shown to contain amyloid-β (Aβ) conformer-specific IgG autoantibodies [2] that could be involved in the beneficial effects observed in the phase II study. Here we asked the question whether GGL contains other antibodies and soluble proteins that can modulate the Aβ transport/ clearance apart from these anti-Aβ auto-antibodies. In N-terminal human RAGE peptide AQNITARIGEPLVLKCKGAPKKPP QRLEWKLN Y