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P1‐071: Familial and sporadic Alzheimer's disease: A clinical longitudinal study
Author(s) -
Talarico Giuseppina,
Tosto Giuseppe,
Piacentini Elisa,
Canevelli Marco,
Pignatelli Marco,
Piscopo Paola,
Crestini Alessio,
Careggi Lorenzo Malvezzi,
Confaloni Annamaria,
Gasparini Marina,
Salati Manuela,
Lenzi Gian Luigi,
Vanacore Nicola,
Bruno Giuseppe
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.075
Subject(s) - medicine , proband , disease , dementia , family history , neurological examination , psen1 , clinical dementia rating , age of onset , early onset alzheimer's disease , alzheimer's disease , pediatrics , presenilin , genetics , psychiatry , mutation , biology , gene
Background: In MMST test the attention, calculation and working memory are being tested by making the patients count from 100 down 7 by 7. Alternatively by testing them to spell the ‘WORLD’ backward. The aim of this study is to compare the two methods for finding the relation of age, sex and education on the total MMST score. Methods: The subjects were chosen among dementia patients coming from 9 centers (TAC-Turquaz Alzheimer Study Group) which had come to be examined for for the first time. Fourhundred fortynine subjects (165 male, 284 female) older than 55 years were analyzed whose MMSE scores are in between 10 to 24. All the participants answered the questions of MMST and the evaluation are made over total score of 30. The subjects were asked to count 100 down 7 by 7 and also to spell the word ‘World’ backwards. Results: The mean MMSE score is 22.2664.76 in spelling the word ‘‘WORLD’’ backwards, the mean MMSE score is 18.964.29 in counting 100 down 7 by 7. We found statisticaly significant set as p1⁄40.0001 between two tests, there is a negative correlation between the age and the test scores (p1⁄40.001, r1⁄40.168) were established, We found also there is no affect of gender on the test scores (p>0.05). Conclusions: While making the clinical diagnosis, standardized alternative tests according to age and education give out more precise information.