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P1‐025: Peripheral administration of lipopolysaccharide induces a deficit in a rodent spatial learning and memory task
Author(s) -
Wong Fong Kuan K.,
Chen Woei Shin S.,
Wong Peter Tsun Hon T.H.,
Frederick Paul,
Chapman F.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.028
Subject(s) - dentate gyrus , morris water navigation task , spatial learning , inflammation , barnes maze , analysis of variance , medicine , water maze , neuroscience , rodent , peripheral , lipopolysaccharide , central nervous system , hippocampus , psychology , biology , ecology
specific as there were no differences between male hpg and wild-types in the cerebellum or the rest of the brain. Male uninjured hpg mice also had lower ChAT expression in the basal forebrain than wild-types, and lower IL-1b levels throughout the brain. These differences were gender specific as there was no difference in these proteins between female hpg and wild-types. Hpg mice had significantly higher levels of APP, PS1 and apoE after injury than injured wild-type mice. Conclusions: Hpg mice provide a useful alternative to examine the relationships between sex hormones and proteins related to AD. Male, but not female, hpg mice have altered levels of proteins related to AD perhaps suggesting that androgens may regulate levels of these proteins. Finally, depletion of sex hormones may exacerbate the response to brain injury as hpg mice have higher levels of APP, PS1 and ApoE.