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P1‐401: Identification of novel APP/Aβ isoforms in human cerebrospinal fluid
Author(s) -
Portelius Erik,
Brinkmalm Gunnar,
Tran Ai Jun,
Zetterberg Henrik,
Westman-Brinkmalm Ann,
Blennow Kaj
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.983
Subject(s) - amyloid precursor protein , chemistry , peptide , gene isoform , tandem mass spectrometry , amyloid precursor protein secretase , peptide sequence , biochemistry , cerebrospinal fluid , microbiology and biotechnology , alzheimer's disease , biology , mass spectrometry , chromatography , disease , medicine , neuroscience , gene
100 to 10,000-fold gain in sensitivity compared to conventional ELISA. It also reveals a set of additional advantages. Results: We show the high sensitive detection of different Alzheimer’s disease (AD) related biomarkers, e.g. phosphorylated TAU. Additionally, we could decrease the needed sample volume to only some microliter still showing an improved sensitivity compared to standard immunoassays. Conclusions: These results show ways for improved detection and prognosis of CNS biomarkers in AD and related dementias, including parkinsonian movement disorders, and ways for future developments.