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P1‐393: Hypertrophy of CA1‐hippocampal neurons and APOE frequency in asymptomatic Alzheimer's disease: Findings from the Nun Study
Author(s) -
Iacono Diego,
Pletnikova Olga,
Rudow Gay,
Patel Ela,
Tudor Dianna,
Markesbery William R.,
Zandi Peter,
Troncoso Juan C.,
Snowdon David
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.974
Subject(s) - asymptomatic , autopsy , hippocampal formation , hippocampus , pathology , alzheimer's disease , dementia , atrophy , disease , cognitive decline , apolipoprotein e , cognition , neuropsychology , psychology , neuroscience , medicine
subjects, 28 with MCI and 24 with dementia (17 mild), aged 82.2 5.0 years, 56% female and with educational level of 2.9 2.4 years. No correlation was found between apathy scores and any global or executive cognitive measure. This finding were observed in the whole sample and where replicated in the MCI, mildly demented and demented sub-samples. Apathy scores inversely correlated with DAD scores in the demented subjects (r -0.698; p 0.0011). Conclusions: In this community based sample of low-literacy cognitively impaired oldest old elderly, no correlation was found between executive measures and apathy scores. However, higher apathy scores correlated with worse functional performance in the demented patients.