Premium
P1‐344: Plasma amyloid isoforms in non‐Alzheimer's disease patients
Author(s) -
Engelborghs Sebastiaan,
Le Bastard Nathalie,
De Deyn Peter P.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.925
Subject(s) - dementia , medicine , amyloid (mycology) , alzheimer's disease , gene isoform , disease , gastroenterology , oncology , pathology , endocrinology , chemistry , biochemistry , gene
Background: Plasma amyloid biomarkers are under research as diagnostic tools for AD. The performance of these biomarkers in other types of dementia has not yet been investigated. In order to determine the diagnostic performance of these plasma amyloid biomarkers in other types of dementia, we set up a study evaluating the plasma -amyloid1-40 protein (A 1-40) and -amyloid1-42 protein (A 1-42) isoforms in patients with non-Alzheimer’s disease (NON-AD) dementias and healthy elderly. Methods: Plasma samples from 46 NON-AD patients (FTD: N 21; DLB: N 14; VAD: N 11; CJD: N 3) and 49 healthy elderly were included. Ten NON-AD patients had neuropathologically confirmed diagnoses. All plasma samples were selected from the Biobank facilities, Institute Born-Bunge. Plasma levels of A 1-40 and A 1-42 were determined with a commercially available multi-parameter bead-based immuno-assay. Results: Compared to healthy elderly, NON-AD patients showed a significantly higher plasma A 1-42/ A 1-40 ratio (p 0.019), while plasma A 1-40 (p 0.902) and A 1-42 (p 0.056) were not significantly different. The ROC curve for the A 1-42/A 1-40 ratio yielded an AUC of 0.643 with an optimal cut-off value of 0.112 (sensitivity 80%; specificity 27%). Conclusions: This data suggests that plasma A 1-40 and A 1-42 isoforms have a diagnostic value for NON-AD dementias and that plasma A 1-40 and A 1-42 isoforms might be useful for discriminating NON-AD patients from healthy elderly.