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P1‐335: The neuronal substrate of amnestic syndrome in Alzheimer's disease: A VBM and volumetric MRI study
Author(s) -
Chauviré Valérie,
Sarazin Marie,
Chupin Marie,
Kinkingnéhun Serge,
Colliot Olivier,
Sousa Léonardo Cruz,
Hahn Barma Valérie,
Dormont Didier,
Lehéricy Stéphane,
Dubois Bruno
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.916
Subject(s) - episodic memory , psychology , parahippocampal gyrus , free recall , audiology , atrophy , neuropsychology , hippocampus , recall , temporal lobe , neuroscience , medicine , cognition , cognitive psychology , epilepsy
sion weighted images acquired at 3T (Philips Achieva; Philips Medical Systems, Best, Netherlands) and neuropsychological data were collected from the same participants. Results: These different modalities were combined in a novel paradigm; grey matter volume, FDG uptake; regional probabilistic indices of connectivity and cognitive function were measured. The relationship between these different factors is discussed with respect to brain function in individuals with Alzheimer’s disease and individuals at risk of developing Alzheimer’s disease. Conclusions: The data from the present study demonstrates that when using convergent investigative techniques significant changes in cognition and within the brain associated with Alzheimer’s disease can be detected at an early stage.