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P1‐290: Increased rate of volumetric white matter hyperintensity progression predicts cognitive impairment in healthy elderly
Author(s) -
Silbert Lisa C.,
Nelson Catherine,
Howieson Diane,
Moore Milar M.,
Kaye Jeffrey A.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.880
Subject(s) - hyperintensity , medicine , brain size , white matter , cardiology , magnetic resonance imaging , cognitive impairment , cognitive decline , dementia , radiology , disease
are in agreement with the well established spatial distribution of neurofibrillary AD pathology. Rates of GM density loss were signifiacnt in the medial and basal temporal lobe, posterior cingulate/precuneus, lateral temporal-parietal neocortex, and subfrontal regions. Figures 1 and 2 are maps of GM loss in the AD test and AD retest groups, respectively (p 0.05, FDR corrected). Little difference is seen in the topography of rate of GM loss between the completely independent test and retest groups of AD subjects. A test vs. retest difference map showed no significant voxels, thus illustrating the stability of the TBM method. Conclusions: We implemented an automated TBM algorithm in SPM5. The algorithm demonstrated excellent test-retest reproducibility in independent subject samples. The maps displaying rates of atrophy agree quite well with the expected anatomic distribution of greatest neuronal pathology in AD. P1-290 INCREASED RATE OF VOLUMETRIC WHITE MATTER HYPERINTENSITY PROGRESSION PREDICTS COGNITIVE IMPAIRMENT IN HEALTHY ELDERLY