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P1‐270: A direct comparison between two volumetric measurement techniques using subjects participating in the multi‐centre Alzheimer's disease neuroimaging initiative
Author(s) -
Nestor Sean M.,
Rupsingh Raul,
Borrie Michael,
Smith Matthew,
Accomazzi Vittorio,
Wells Jennie,
Bartha Robert
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.860
Subject(s) - intraclass correlation , alzheimer's disease neuroimaging initiative , magnetic resonance imaging , neuroimaging , dementia , ventricle , medicine , third ventricle , cardiology , cognitive impairment , nuclear medicine , disease , psychology , radiology , psychiatry , clinical psychology , psychometrics
FDG-PET were examined for longitudinal CMRglc declines. Results: As compared to FHand FHp, FHm subjects showed CMRglc reductions in the same regions as clinical AD patients, i.e. posterior cingulate cortex/precuneus (PCC), parieto-temporal, frontal and medial temporal cortices (P’s 0.05, corrected for multiple comparisons). These effects remained significant after accounting for age, gender, education, and ApoE genotype. No CMRglc differences were found between FHp and FH-. CMRglc reductions in FHm as compared to FHand FHp reached statistical significance at age 55 years. CMRglc declined at greater rates in FHm as compared to FHand FHp, and was further reduced by 13-23% in those FHm with the mother and maternal grandmother affected with AD (n 6) (P’s 0.05). Conclusions: NL individuals with a maternal history of AD show hypometabolism in AD-vulnerable brain regions. The CMRglc reductions occur at middle age, are progressive, and are more severe in those with a maternal history of AD spanning two generations. FDG-PET measures may help to identify NL individuals at risk for future AD years in advance of clinical symptoms, and to direct investigation of potential susceptibility genes for AD.