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P1‐251: The Australian Normative and Dementia Imaging (ANDI) collaborative network: Software tools for large databases
Author(s) -
Janke Andrew L.,
Budge Marc
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.841
Subject(s) - neuroimaging , dementia , identification (biology) , normative , data science , computer science , radiological imaging , field (mathematics) , medical imaging , medical physics , artificial intelligence , medicine , psychology , pathology , neuroscience , radiology , philosophy , botany , mathematics , disease , epistemology , pure mathematics , biology
A accumulation in FTD patients. Methods: We studied fifteen patients of FTD and fifteen patients with AD meeting the diagnostic criteria and six subjects as healthy controls. All the subjects underwent PET study with C-PIB and F-FDG. All the patients were followed up clinically at least one year. Three FTD patients had two C-PIB scans with one-year interval, and nine FTD patients had multiple F-FDG PET scans to monitor the disease progression. The C-PIB accumulation was evaluated with the summing image from 40 to 60 min after the injection with the cerebellar cortex was used as a reference region. The images were evaluated by visual inspection, measurements with regions of interest, and statistical analysis with statistical parametric mapping (SPM). Results: Three FTD patients had C-PIB accumulation as high as the level of AD group. Those patients may be the contamination of AD as the limitation of clinical diagnostic criteria. In the rest of 12 FTD patients, the average of C-PIB accumulation was not significantly higher than that of healthy controls. However, four of them had mild C-PIB accumulation, and three of them underwent follow up C-PIB scan revealing increasing C-PIB accumulation in one-year follow up. The FTD patients with increasing C-PIB accumulation have a trend to demonstrate relatively rapid progression of the clinical symptoms in comparison with the patients with negative C-PIB accumulation. Conclusions: Mild increase in C-PIB accumulation was observed in about a quarter of FTD patients who showed relatively rapid progression of the symptoms. Besides normal aging, A burden may have some pathological role in FTD. Further prospective study and pathological correlation study are required.