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P1‐228: Comparison of amyloid plaque contrast generated by T 2 ‐, T 2 * , and susceptibility‐weighted magnetic resonance imaging methods in transgenic mice
Author(s) -
Chamberlain Ryan M.,
Reyes Denise,
Curran Geoffrey L.,
Marjanska Malgorzata,
Wengenack Thomas M.,
Poduslo Joseph F.,
Garwood Michael,
Jack Clifford R.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.817
Subject(s) - spin echo , gradient echo , magnetic resonance imaging , ex vivo , echo (communications protocol) , contrast (vision) , susceptibility weighted imaging , nuclear magnetic resonance , nuclear medicine , fast spin echo , pulse sequence , echo time , in vivo , medicine , radiology , physics , biology , optics , computer science , computer network , microbiology and biotechnology
cognition. Results: Change in WMH was significantly greater for AD patients than CN or MCI (Tables 2), but was not influenced by scanner or site. Higher WMH volume at baseline was significantly associated with greater declines in MMSE, category fluency, and Boston Naming measures, consistent with previous studies emphasizing relationships between frontal mediated cognitive task performance and WMH (Table 3). Greater increase in WMH volume was also significantly associated with greater declines in MMSE and multiple measures of executive function (Table 4). Conclusions: A change in WMH was significantly greater for AD patients than CN or MCI (Tables 2), but was not influenced by scanner or site. Higher WMH volume at baseline was significantly associated with greater declines in MMSE, category fluency, and Boston Naming measures, consistent with previous studies emphasizing relationships between frontal mediated cognitive task performance and WMH (Table 3). Greater increase in WMH volume was also significantly associated with greater declines in MMSE and multiple measures of executive function (Table 4).