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P1‐165: Association of prior stroke with mild cognitive impairment: A population‐based study
Author(s) -
Knopman David S.,
Roberts Rosebud O.,
Geda Yonas E.,
Boeve Bradley F.,
Pankratz V. Shane,
Cha Ruth H.,
Tangalos Eric G.,
Rocca Walter A.,
Petersen Ronald C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.753
Subject(s) - dementia , stroke (engine) , cognition , neuropsychology , population , odds ratio , medicine , medical diagnosis , quartile , medical history , psychology , psychiatry , clinical psychology , disease , confidence interval , pathology , environmental health , mechanical engineering , engineering
(WMH) in 91 patients with single domain amnestic MCI (aMCI), 32 patients with multiple domain aMCI, 20 patients with single or multiple domain non-amnestic MCI (naMCI), and 100 age and gender matched cognitively normal (CN) subjects. Hippocampal volumes were converted to age and gender normalized W-scores. Mayo Older American Normative Studies (MOANS) age-adjusted scaled scores were used for all neuropsychological variables. A mean MOANS score was created for each domain. Results: Single domain aMCI subjects had hippocampal atrophy and elevated myoinositol/Creatine (mI/Cr) ratio compared to CN subjects (p 0.001). Patients with naMCI had normal hippocampal W-scores and HMRS metabolite ratios compared to CN subjects, but a greater proportion of them had cortical infarctions compared to single domain aMCI subjects (p 0.003). The MR findings in multiple domain aMCI patients were overlapping with both the single domain aMCI and naMCI patients. Hippocampal W-scores positively correlated with memory function (p 0.01) (Figure), and cortical and subcortical infarctions were associated with impairment in non-memory cognitive domains (p 0.03) in MCI. WMH was overall greater in MCI than CN, but not different among MCI subtypes, and did not correlate with domain specific impairments. Conclusions: MRI and HMRS findings in patients with single domain aMCI are characterized by AD related changes such as elevated mI/Cr and hippocampal atrophy. NaMCI patients, do not have the MR features of AD but more frequently have cortical infarctions. MR findings in multiple domain MCI patients show similarities to both single domain aMCI and naMCI. Despite the overlap in MR findings between the MCI subtypes, our data suggests that single domain aMCI patients have more AD pathology and naMCI patients have more cerebrovascular disease underlying cognitive impairment.