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P1‐103: Comparison of species‐typical and social behaviors in two double‐transgenic mouse models of Alzheimer's disease at 12 months of age
Author(s) -
Brown Richard E.,
Hernandez-Lee Jacalynne,
Gunn Rhian K.,
Duffy Kevin
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.690
Subject(s) - habituation , wild type , genetically modified mouse , psychology , morris water navigation task , developmental psychology , transgene , psen1 , presenilin , neuroscience , endocrinology , medicine , alzheimer's disease , hippocampus , disease , biology , genetics , gene , mutant
Background: Rodent models of Alzheimer’s disease have become indispensable for the study of genetic, neural and behavioral deficits found in Alzheimer’s disease. Methods: We compared two double transgenic mouse models of Alzheimer’s disease, B6C3-Tg(APPSwe,PSEN1dE9)85Dbo/J (APP PS1dE9; JAX # 004462) and B6C3-Tg(APP695)3DboTg(PSEN1)5Dbo/J (APP695 PSEN1; JAX# 003378) and their wildtype controls in tests of anxiety (light/dark transition box), species-typical behavior (nest building, food hoarding), social memory (social recognition, social transmission of food preference) olfactory learning and memory (habituation-dishabituation) and spatial learning and memory (Morris water maze) at 12 months of age. Results: Both transgenic mouse strains showed increased anxiety compared to their littermate controls. The APP PS1dE9 strain did not differ from their wildtype controls in nest building, but the APP695 PSEN1 strain built poorer nests than their wildtype. The APP695 PSEN1 transgenic mice and their wildtype littermates hoarded more food than the APP PS1dE9 mice and their wildtype littermates, thus this appears to be a background strain effect. All mice showed sociability in the social recognition task, but none showed a preference for social novelty. The APP PS1dE9 and their wildtype littermates showed a greater latency to explore novel odors than APP695 PSEN1 and their wildtype littermates, and the transgenic mice explored the odors longer than wildtype mice. There was no difference in social transmission of food preference, although the APP659 PSEN1 and their wildtype littermates ate more of the novel food than the APP PS1dE9 and their wildtype littermates. The APP695 PSEN1 and their wildtype littermates ate more food overall than the APP PS1dE9 and their wildtype littermates, and the APP695 PSEN1 transgenic mice ate the most food overall. The APP PS1dE9 transgenic strain showed more Congo red stained amyloid beta plaques in the hippocampus and cortex than the APP695 PSEN1 transgenic strain at 12 months of age. Conclusions: These results suggest that despite having fewer amyloid plaques in the brain, the APP695 PSEN1 mouse shows more behavioral deficits than the APP PS1dE9 mouse at 12 months of age. We are examining other neuro-behavioral differences between these strains in longitudinal studies.