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P1‐090: Misfolded truncated tau‐induced oxidative stress is mediated by specific subgroup of reactive oxygen species in a rat model of tauopathy
Author(s) -
Cente Martin,
Filipcik Peter,
Krajciova Gabriela,
Novak Michal
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.676
Subject(s) - oxidative stress , reactive oxygen species , tauopathy , mitochondrion , chemistry , tau protein , depolarization , oxidative phosphorylation , microbiology and biotechnology , biology , biochemistry , neurodegeneration , medicine , biophysics , alzheimer's disease , disease
tathione (see also poster by Choudhry et al, this meeting) and synaptophysin levels were unaffected by diet, gender and transgene expression. Levels of drebrin (here used as a marker of post-synaptic glutamatergic synapses) were significantly different by gender and genotype, and further altered by interactions between gender and diet, diet and genotype and gender, diet and genotype. VGLUT1 expression was significantly altered by genotype alone. Conclusions: These data suggest a pertubation in glutamatergic signalling in those trangsenic mice receiving this pro-oxidant diet. Moreover, these data suggest this transgenic model may be of use in testing and validation of biomarkers.