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P1‐071: High resolution 1d and 2d analysis of A‐beta peptides in plasma, Csf and brains of APP23 transgenic mice
Author(s) -
Klafki Hans W.,
Schieb Heinke,
Paul Sabine,
Esselmann Hermann,
Leuthäusser Sabine,
Maler Juan Manuel,
Bibl Mirko,
Staufenbiel Matthias,
Wiltfang Jens
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.657
Subject(s) - neuropathology , isoelectric focusing , microbiology and biotechnology , genetically modified mouse , amyloid precursor protein , alzheimer's disease , peptide , amyloid (mycology) , chemistry , isoelectric point , transgene , biology , biochemistry , pathology , gene , medicine , disease , enzyme , inorganic chemistry
frontal cortex gliosis was observed in APP mice that was absent in the APP / 7KO group and the same trend for gliosis was seen in the hippocampus although this result did not reach statistical significance. These results are even more striking by the fact that levels of -amyloid and amyloid plaques were not different between APP and APP / 7KO mice. Conclusions: Taken together, these results predict that blocking 7nAChR might protect against neurodegeneration and cognitive decline induced by -amyloid. Further characterization of this novel mice model of slowed AD is in progress. Funded by: NIH grant #5 P01 AG010435-16.