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P1‐054: Early and advanced stages of Tau aggregation in transgenic mouse models
Author(s) -
Zabke Claudia,
Dietze Silke,
Stamer Karsten,
Rickard Janet E.,
Harrington Charles R.,
Theuring Franz,
Seng Kwang Meng,
Wischik Claude M.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.640
Subject(s) - tau protein , genetically modified mouse , tauopathy , gene isoform , transgene , epitope , biology , in vivo , microbiology and biotechnology , chemistry , alzheimer's disease , gene , antibody , pathology , biochemistry , genetics , neurodegeneration , medicine , disease
cephalic nuclei of the fifth nerve, reticular formation, and dentate cerebellar nucleus across age and gender. The neurons in the inferior colliculus and pretectum were also immunoreactive for Alz50 across gender and age, while Alz50 immunoreactive reticular neurons were first seen in females at 6 months and later in males at 9 months. Interestingly, substantia nigra neurons were only A (6E10) immunoreactive across groups and time points. In general, 6E10 staining was most prevalent in the examined brainstem areas followed by Alz50 and then AT8. As animals aged, there was a proportional increase in staining. Conclusions: These findings indicate that brainstem neurons of the 3xTg-AD mouse contain AD-like A and tau intraneuronal pathology reminiscent of the human disorder. The functional consequences of these neuronal brainstem pathologies remain to be defined.