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P1‐026: Intracellular Aβ triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease
Author(s) -
Christensen Ditte Z.,
Bayer Thomas A.,
Wirths Oliver
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.611
Subject(s) - nucleus basalis , cholinergic neuron , cholinergic , basal forebrain , neuroscience , choline acetyltransferase , neuron , biology , hippocampus , striatum , medial forebrain bundle , hippocampal formation , forebrain , central nervous system , dopamine
amyloid plaques in young 3xTg-AD mice. Plaque deposition was sex dependent with females showing more plaques than males beginning at 9 months predominately in the subiculum and to a lesser degree in the hippocampus, cortex and amygdala. Conclusions: These results stress the importance of fixation method for the immunohistochemical visualization of tau epitopes in young 3xTg-AD mice, and that intraneuronal A is not necessarily a precondition for the concurrent staining of tau epitopes in select brain regions in these mutant mice.