Premium
O4‐05–04: Depressive symptoms and incidence of dementia in the very old: The monzino 80‐plus study
Author(s) -
Lucca Ugo,
Garra Mariateresa,
Nobili Alessandro,
Riva Emma,
Tettamanti Mauro
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.539
Subject(s) - dementia , depression (economics) , incidence (geometry) , medicine , geriatric depression scale , population , family history , psychiatry , gerontology , depressive symptoms , pediatrics , disease , cognition , physics , environmental health , optics , economics , macroeconomics
cognitive decline of AD patients reporting or not CVDRF was assessed using the MMSE and the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog), after 2 years of follow-up. Results: Of the 629 patients at baseline, 268 (42.6%) reported absence of CVDRF, 256 (40.7%) reported 1 CVDRF and 105 (16.7%) reported 2-3. At inclusion, hypertension was present in 44.1% of patients, hypercholesterolemia in 22.6% and diabetes in 9.4%. No statistical significant differences (p values of 0.9 for MMSE and 0.8 for ADAS-Cog) of mean cognitive declines after 2 years of follow-up were found comparing different subgroups of patients with CVDRF to the non-CVDRF group. Conclusions: Although there is evidence that CVDRF contribute to the onset of AD, these results suggest that CVDRF may not be part of the underlying processes that affect progression of AD.