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O4‐05–03: The apolipoprotein E‐epsilon 2 allele is associated with increased Alzheimer neuropathology but preserved cognition: Findings from the 90+ study
Author(s) -
Berlau Dan,
Corrada Maria,
Head Elizabeth,
Kawas Claudia
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.538
Subject(s) - neuropathology , apolipoprotein e , dementia , psychology , alzheimer's disease , medicine , neuropsychology , odds ratio , pathological , genotype , pathology , disease , cognition , psychiatry , genetics , biology , gene
cognitive decline of AD patients reporting or not CVDRF was assessed using the MMSE and the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog), after 2 years of follow-up. Results: Of the 629 patients at baseline, 268 (42.6%) reported absence of CVDRF, 256 (40.7%) reported 1 CVDRF and 105 (16.7%) reported 2-3. At inclusion, hypertension was present in 44.1% of patients, hypercholesterolemia in 22.6% and diabetes in 9.4%. No statistical significant differences (p values of 0.9 for MMSE and 0.8 for ADAS-Cog) of mean cognitive declines after 2 years of follow-up were found comparing different subgroups of patients with CVDRF to the non-CVDRF group. Conclusions: Although there is evidence that CVDRF contribute to the onset of AD, these results suggest that CVDRF may not be part of the underlying processes that affect progression of AD.