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O4‐05–01: Longitudinal analysis of the association between depressive symptoms and dementia: The three‐city (3c) study
Author(s) -
Lenoir Hermine,
Godin Ophelia,
Lacombe Jean-Marc,
Dufouil Carole,
Ritchie Karen,
Dartigues Jean-François,
Alperovitch Annick,
Tzourio Christophe
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.536
Subject(s) - dementia , depression (economics) , medicine , incidence (geometry) , longitudinal study , logistic regression , epidemiology , depressive symptoms , psychiatry , cognition , disease , pathology , physics , optics , economics , macroeconomics
teria were randomized to receive treatment with either 1 mg micronized E2 (Estrace, Shire Biochem Inc., Quebec, Canada) or placebo for 12 weeks following which they were crossed-over to the other treatment for an additional 12 weeks. All subjects thus received both micronized E2 and placebo. The Buschke Serial Reminding task , the Logical Memory 1 & 2 paragraph recall test of the Wechsler Memory Scale-Revised, and the Paired Associates Learning subtest of the WMS-R were used to assess short and long term verbal memory. The Visual Reproduction subtest of the WMS-R was used to assess visual memory. The Mini-Mental Status exam (MMSE) and the Alzheimer’s disease Assessment Scale-Cognitive Subscale (ADAS-Cog) were used to assess global cognitive function. Results: Men who received 12 weeks of treatment with E2 following 12 weeks of treatment with placebo had significantly higher total score on the Buschke Serial Reminding Task total score (p .05), and on three subscales of that test, namely, the Long Term Recall score (p .05), on the Continuous Long Term Recall score (p .05) and on the Delayed Recall score (p .05) compared to their performance at baseline and following 12 weeks of treatment with placebo. Non-verbal memory and global measures showed no significant difference between placebo and estrogen. Conclusions: A beneficial effect of E2 on verbal memory in MCI individuals was confirmed. The hypothesis that estrogen-treatment would improve scores on measures of global cognitive functioning in these male MCI subjects was not supported.