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O3‐06–03: Profiles of longitudinal brain atrophy in semantic dementia
Author(s) -
Rohrer Jonathan D.,
McNaught Elizabeth,
Foster Jo,
Clegg Shona,
Barnes Josephine,
Omar Rohani,
Rossor Martin,
Warren Jason,
Fox Nick
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.452
Subject(s) - atrophy , temporal lobe , dementia , frontotemporal lobar degeneration , semantic dementia , cardiology , medicine , hippocampus , psychology , pathological , frontotemporal dementia , pathology , neuroscience , disease , epilepsy
and cognitive impairment based on comprehensive neuropsychological and behavioral assessment, 2) who had comparative MRI scans (excluding vascular lesions and assessing atrophy) and SPECT 3) and who were examined by a senior neurologist and a senior psychiatrist that could count on a reliable informant. Results: Out of 77 patients fulfilling the criteria of fv-FTD followed-up for at least 3 years (including 5 with autopsy), 11 did not show any progression of the disease. Median age at onset was 54 years (37-69), median follow-up was 6 years (4-12). All patients had 5/5 core diagnostic features except 2 who did not have significant decline in social interpersonal conduct. They had a median of 3 (1-5) out of 6 behavioral supportive diagnostic features. The Frontotemporal Behavioral Scale was 5 in 5 patients and 4 in 4 patients. Median anxiety Hamilton score was 21 (8-45). Six patients had aspontaneity and economy of speech, 1 had stereotypy of speech, and 1 had a press of speech. Eight patients had a history of depression, and 4 a family history of psychiatric disorders; 6 had vascular risk factors (hypercholesterolemia n 5, hypertension n 2, tobacco n 1). The diagnosis remained FTD after a median of 8 years (4-12) of follow-up in 5 patients and the final diagnosis was dementia in the context of bipolar disorders in 6 patients (median follow-up: 6 years [5-12]). No initial feature could distinguish between the 2 groups, although perseverative, stereotyped behavior, mental rigidity, inflexibility, delusion, thoughtless spending, delirium and fluctuations were more frequent in the group with bipolar disorders. Conclusions: Bipolar disorders should be considered as a differential diagnosis of long-lasting fv-FTD.