Premium
O3‐03–03: Apolipoprotein E4 and its fragment impair mitochondrial dynamics in neuronal cultures
Author(s) -
Brodbeck Jens,
Balestra Maureen,
Freedman Stephen,
Weisgraber Karl H.,
Mahley Robert W.,
Huang Yadong
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.425
Subject(s) - biology , mitochondrion , microbiology and biotechnology , apolipoprotein e , neurodegeneration , motility , depolarization , synapse , neurite , biochemistry , neuroscience , in vitro , medicine , endocrinology , disease
internalization and cell viability in CBVs were increased when they were coincubated with conditioned media with high concentrations of apoE and with A . No internalization of A was observed in astrocytes, however. Conclusions: These results implicate that apoE has a more important role in regulating A internalization and A -mediated cytotoxicity in CBVs, than in astrocytes, which may be relevant to the process of A clearance across the blood brain barrier.