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O3‐02–07: Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
Author(s) -
Richardson Jill C.,
Cogswell John P.,
Ward James,
Taylor Ian A.,
Waters Michelle,
Shi Yunling,
Can Brian,
Kelnar Kevin,
Kemppainen Jon,
Brown David,
Chen Caifu,
Prinjha Rab K.,
Saunders Ann M.,
Roses Allen D.,
Richards Cynthia A.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.420
Subject(s) - microrna , biology , neurogenesis , disease , neuroscience , bioinformatics , medicine , gene , pathology , genetics
MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. Using a sensitive qRT-PCR platform we identified regional and stage-specific deregulation of miRNA expression in AD patient brains. We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease.