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O3‐01–03: Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
Author(s) -
Small Scott,
Duff Karen,
Arancio Ottavio,
Ganetzky Barry,
Honig Lawrence
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.407
Subject(s) - retromer , neurodegeneration , hippocampal formation , neuroscience , microbiology and biotechnology , biology , alzheimer's disease , endocrinology , chemistry , medicine , endosome , disease , intracellular
(p 0, 01) and grip hanging task (p 0,05), compared to age-matched untrained APP/PS1KI mice. No difference in the swimming distance could be detected and the swimming pattern was as impaired as the one displayed by the untrained APP/PS1KI mice. Interestingly, the enriched environment failed to restore the neurogenesis and didn’t result in any improvement of the working memory. Reduced neurogenesis measured by doublecortin staining in the dentate gyrus of APP/PS1KI mice was already visible at 2 months of age (62%, p 0.05), resulting in a complete loss of the of doublecortin signal at the age of 6 months. Conclusions: Enriched environment has a beneficial effect on some motor abilities of APP/PS1KI mice however hippocampal dysfunction could not be restored. We speculate that the fast and severe neuron loss in hippocampus can not be modulated by increasing neurogenesis in the dentate gyrus. Enriched environment has however significant beneficial effects on motor performance and may be translated to some symptoms reported in AD patients.