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S3‐05–01: Efficacy of behavioral interventions to improve sleep in adult family homes
Author(s) -
McCurry Susan
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.399
Subject(s) - medicine , actigraphy , dementia , psychological intervention , randomized controlled trial , physical therapy , gerontology , insomnia , psychiatry , surgery , disease , pathology
months. Results: The extent of A deposition and the accumulation of insoluble A was significantly reduced in Tg2576/Irs2 mice compared to Tg2576 controls but tau phosphorylation was significantly increased compared to both Tg2576 and Irs2 animals. APP processing and soluble A levels were not altered, but insulin degrading enzyme showed altered localisation, suggesting that reduced A deposition may be due to increased degradation/clearance. Increased tau phosphorylation correlated with a reduction in PP2A, activity. The tau-kinase glycogen synthase kinase -3 (GSK-3) was inhibited and behavioural deficits were reversed in Tg2576/Irs2 mice. Conclusions: Our findings demonstrate that deletion of Irs2 in Tg2576 mice has divergent effects on pathological processes related to Alzheimer’s disease a reduction in plaques but an increase in tau phosphorylation accompanied by improvement in behaviour. These findings suggest that manipulation in insulin signalling in man as a therapeutic strategy might have similarly complex effects.