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O2‐06–06: SNPS in MAPT are associated with cerebrospinal fluid Tau levels, MAPT mRNA levels, and age at onset of late‐onset Alzheimer's disease
Author(s) -
Kauwe John S.K.,
Cruchaga Carlos,
Mayo Kevin,
Fenoglio Chiara,
Bertelsen Sarah,
Nowotny Petra,
Galimberti Daniela,
Scarpini Elio,
Shah Aarti R.,
Morris John C.,
Fagan Anne M.,
Holtzman David M.,
Goate Alison M.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.354
Subject(s) - single nucleotide polymorphism , tau protein , endophenotype , cerebrospinal fluid , medicine , minor allele frequency , allele , alzheimer's disease , disease , endocrinology , oncology , genotype , biology , psychology , genetics , neuroscience , gene , cognition
sure(p 0.003), higher diastolic blood pressure (p 0.001) and more symptoms of atherosclerosis as measured with the Ankle Arm index (P 0.001) when compared to offspring without such a family history. Production capacity of cytokines in offspring with a parental history of Alzheimer’s disease was also different with higher levels of Interleukin-1 (p 0.002), Interleukin-1 to Interleukin-1ra ratio (p 0.001), Tumour Necrosis Factor(p 0.01) and Interleukin-6 (p 0.003). These findings were independent of ApoE4 carriership. Conclusions: Vascular factors and a pro-inflammatory cytokine profile are heritable factors expressed at middle age that contribute to Alzheimer’s disease in late age.