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IC‐P2‐072: Automated 3D mapping of caudate atrophy and ventricular enlargement in Parkinson's disease with and without dementia
Author(s) -
Apostolova Liana G.,
Beyer Mona K.,
Green Amity E.,
Chou Yi-Yu,
Morra Jonathan H.,
Hwang Kristy,
Aarsland Dag,
Janvin Carmen C.,
Larsen Jan P.,
Toga Arthur W.,
Cummings Jeffrey L.,
Thompson Paul M.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2616
Subject(s) - atrophy , dementia , parkinson's disease , lateral ventricles , cardiology , cognitive decline , medicine , psychology , anatomy , disease
Background: Parkinson’s disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Cognitive decline in PD has been associated with caudate atrophy and ventricular enlargement. Methods: We applied two novel automated segmentation methods for the lateral ventricles (multi-atlas fluid image alignment; Chou et al., 2008) and caudate nuclei (a machine learning algorithm based on adaptive boosting; Morra et al., 2008) in 3D T1-weighted brain MRI scans of 20 cognitively normal elderly (NC), 12 cognitively normal PD, 8 PDMCI and 15 PDD subjects. We then applied the radial distance atrophy mapping approach to examine 3D structural and volumetric differences between the groups. We also investigated associations between the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Mini-Mental State Examination (MMSE) scores and caudate atrophy/ventricular enlargement in 3D. 3D statistical maps were corrected for multiple comparisons using permutation testing thresholded at p 0.01. Results: The PDMCI and PDD groups had significantly lower MMSE and higher UPDRS scores than the PD and NC groups. The 3D statistical maps demonstrated left medial (pcorrected 0.04) and lateral (pcorrected 0.041) and right medial (pcorrected 0.046) caudate atrophy in the PDD vs. the NC group, and right medial (pcorrected 0.033) and lateral (pcorrected 0.013) caudate atrophy in the PDD vs. the PD group. The PDMCI group showed trend level significant (pcorrected 0.056) left lateral caudate atrophy relative to NC. Both the left and the right ventricles were significantly larger in the PDD relative to the NC (left pcorrected 0.03; right pcorrected 0.02) and the PD groups (left pcorrected 0.04; right pcorrected 0.04). Differences were most pronounced in the posterior portions of the lateral ventricles (body/occipital horn). Statistically significant areas showed 20-30% and 5-20% between-group differences for the caudates and the ventricles respectively. PD severity (UPDRS) correlated with both caudate atrophy and ventricular enlargement. Cognitive decline (MMSE) correlated with atrophy of the caudate head and expansion of the body, temporal and occipital horns of the lateral ventricles. Conclusions: Cognitive decline in PD is associated with caudate head atrophy and ventricular enlargement. Caudate atrophy showed a stronger association with PD severity. Ventricular enlargement seemed to correlate better with cognitive decline. IC-P2-073 FEASIBILITY AND TEST-RETEST RELIABILITY OF FMRI IN AN ALZHEIMER’S DISEASE CLINICAL TRIAL