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IC‐P2‐153: Brain MRI and the prediction of survival: An observational follow‐up study in old people without dementia
Author(s) -
Whalley Lawrence J.,
Staff Roger T.,
Murray Alison D.,
Ahearn Trevor,
Starr John M.,
Deary Ian J.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2607
Subject(s) - dementia , medicine , brain size , disease , longitudinal study , ageing , cognitive decline , atrophy , pathology , magnetic resonance imaging , radiology
Analysis of ROIs in the above areas showed the CC group to have intermediate levels of increased or decreased activation between the MCI group and controls depending on the region. Conclusions: FMRI probes of working memory show potential for early detection of AD. Older adults with cognitive complaints demonstrate a similar but intermediate pattern of abnormality during working memory processing. This suggests that abnormal patterns of brain activity on fMRI can indicate brain dysfunction before the onset of MCI and may be more sensitive than neuropsychological testing.