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IC‐P2‐145: Whole‐brain atrophy rate and CSF biomarker levels in MCI and AD: A longitudinal study
Author(s) -
Flier Wiesje M.,
Sluimer Jasper,
Bouwman Femke,
Vrenken Hugo,
Blankenstein Marinus A.,
Barkhof Frederik,
Scheltens Philip
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2599
Subject(s) - atrophy , cerebrospinal fluid , biomarker , medicine , lumbar puncture , gastroenterology , brain size , lumbar , pathology , cardiology , magnetic resonance imaging , surgery , radiology , chemistry , biochemistry
lobe atrophy rate was the only predictor. Conclusions: These data illustrate how atrophy spreads through the brain with the progression of AD. In MCI, the temporal lobe shows the greatest atrophy rate. In AD patients, the medial temporal lobe shows an atrophy rate comparable to MCI, while the remaining part of the temporal lobe demonstrates an even higher rate of atrophy. Moreover, atrophy also accelerates in parietal, frontal, insular and occipital lobes. Finally, in non-demented elderly medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the importance of this region in the early detection of AD.