Premium
IC‐P1‐069: Functional MRI of hippocampal subfields in healthy aging and Mild Cognitive Impairment
Author(s) -
Yassa Michael A.,
Albert Marilyn S.,
Gallagher Michela,
Stark Craig E.L.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2511
Subject(s) - hippocampal formation , neuroscience , hippocampus , episodic memory , psychology , neurocognitive , dentate gyrus , cognition , cognitive impairment , memory impairment , audiology , medicine
(VBM) method. Methods: Severity of EDS was measured by the total score of the six items of the environment dependency category in modified Manchester Behavior Inventory. Sixty nine patients with Alzheimer’s disease, frontotemporal lobar degeneration, corticobasal degeneration, and twenty two normal controls were evaluated. Total scores of the EDS were correlated with structural MRI gray matter volume using VBM. Results: EDS was observed in 46 patients (67%). Voxels in the left inferior frontal gyrus, right medial and lateral superior fontal gyrus, left supplementary motor area, left inferior frontal gyrus, bilateral caudate and putamen, and right inferior temporal gyrus negatively correlated with total EDS scores (P 0.05 , corrected) . Conclusions: EDS is a frequently observed abnormal behavior in patients with neurodegenerative disease. The results suggest that the bilateral frontal and subcortical structures are important in regulating EDS. VBM analysis can reveal the neural basis of the EDS using correlative analytic methods.