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IC‐P1‐062: fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults
Author(s) -
Trivedi Mehul A.,
Murphy Christopher M.,
Goetz Celine,
Shah Raj C.,
Gabrieli John D.E.,
Whitfield-Gabrieli Susan,
Stebbins Glenn T.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2504
Subject(s) - episodic memory , posterior cingulate , neuroscience , psychology , hippocampus , recognition memory , functional magnetic resonance imaging , cognition , audiology , medicine
about 30% in the brain homogenate. When the chemicals were injected into the mouse brain, the most intense signal was detected in TFMB-3Et among three compounds by a single pulse measurement. Also, the chemical shift images(CSI) were clearly observed in TFMB-3Et. When we injected three compounds into a tail vein of APP mice, all compounds were observed in senile plaque. The 19F signal of TFMB-3Et was detected in the brain region of APP transgenic mice. Although the signal noise ratio was relatively high, CSI of TFMB-3Et was observed in the brain. Conclusions: The present result indicates that TFMB-3Et was a candidate derivative for amyloid detection in APP transgenic mice using 19F magnetic resonance imaging.