Premium
IC‐P1‐055: Regional volumetric comparison of gray matter in patients with subcortical ischemic vascular dementia to Alzheimer's disease
Author(s) -
Shim Yong Soo,
Yoon B.R.,
Kim B.S.,
Park Kee Hyung
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2498
Subject(s) - atrophy , vascular dementia , dementia , cardiology , medicine , entorhinal cortex , hippocampus , disease
Background: Subcortical ischemic vascular dementia(SIVD) is a homogenous and common subtype of vascular dementia(VaD), and clinically it shows the gradual progression similar to Alzheimer’s disease(AD), contrary to the usual VaD. Moreover, the findings like the atrophy of brain and the dilatation of ventricle can be also shown on MRI of the patients with SIVD, and some patients with SIVD have the pathology of AD. Therefore there have been opinions that SIVD is actually but the mixed type with AD not the true VaD. We compared the regional volumes of the gray matters between AD and SIVD with the hypothesis that the brain atrophy of the patients with SIVD shown on MRI is a relative result from the atrophy of the white matter, not from the atrophy of the gray matter. Methods: Twelve AD patients meeting the criteria of the NINCDS-ADRDA and 13 SIVD patients meeting the probable VaD criteria of the NINDS-AIREN and Erkinjuntti’s imaging criteria of SIVD were included in this study. Eleven controls were also included. On coronal T1W MRI with the SPGR, the volumes of the bilateral frontal, temporal, parietal and occipital cortex, and the bilateral hippocampus and entorhinal cortex were obtained. After the correction with the ratio to the intracranial volume, the regional volumes were compared among AD, SIVD and the controls by ANOVA with multiple comparisons. Results: Whole brain volumes were not different among three groups. The ventricular volumes of the patients with AD and SIVD were smaller than that of the controls(p 0.001). But, there was no difference between AD and SIVD. For the gray matters, the volumes of all regions were not different between the controls and SIVD patients. The volumes of the bilateral hippocampus(right, p 0.009 and left, p 0.008 and entorhinal cortex(all p 0.002) were the lowest in the AD patients. Conclusions: There can be also observed that the brain atrophy and ventricular dilatation in SIVD as well as in AD. However, these findings of SIVD are not from the cortical atrophy such as the hippocampus and entorhinal cortex, which is responsible for AD, and might be from the lesions of the white matters.