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IC‐01‐06: Amyloid and glucose metabolism in early versus late‐onset AD: A comparative [11C]PIB and [18F]FDG PET study
Author(s) -
Rabinovici Gil D.,
Furst Ansgar J.,
Mormino Elizabeth C.,
O'Neil James P.,
Steed Tyler,
Turken Michael,
Kluth Jennifer,
Madison Cindee,
Miller Bruce L.,
Jagust William J.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2492
Subject(s) - statistical parametric mapping , pittsburgh compound b , medicine , nuclear medicine , positron emission tomography , voxel , gastroenterology , alzheimer's disease , disease , cardiology , magnetic resonance imaging , radiology
the frontal, temporal, parietal , and occipital cortices, posterior cingulate, striatum and cerebellar cortex. Logan graphical analysis was employed to yield estimates of distribution volume (DV) in each regions using the arterial input function, and DV ratios were calculated in each regions with the cerebellar cortex as a reference tissue. PET images were spatially normalized to the MNI space and voxel-by-voxel DVR in the whole brain was also calculated. Group comparisons of DVR in HVs and two patient groups were performed using ANOVA in SPM5 (uncorrected p 0.0001, cluster extent K50 voxels). Results: DVRs were remarkably increased in the frontal ( 49%), lat. temporal ( 54%) and lateral parietal cortices ( 55%), posterior cingulate ( 43%), striatum ( 40%) in the EOAD group compared with HVs (Fig. 1a). DVRs were also remakably increased in the frontal ( 49%), lateral temporal ( 48%), and lateral parietal cortices ( 55%), posterior cingulate ( 52%), striatum ( 35%) in the LOAD group compared with HVs (Fig. 1b). There was no significant difference in DVR in the brain between EOAD and LOAD groups. Conclusions: The results suggest that the degrees and distributions of amyloid deposition are similar in EOAD and LOAD.