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P4‐329: Post HOC responder analyses of Memantine treatment on behavioral disturbances in patients with moderate to severe Alzheimer's disease
Author(s) -
Stender Karina,
Cummings Jeffrey
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2399
Subject(s) - memantine , placebo , post hoc analysis , medicine , population , randomized controlled trial , disease , psychology , dementia , alternative medicine , environmental health , pathology
other part of the study Striatal and CA1 hippocampus glutamate-acetylcholine concentrations of normal and parkinsonian rats after drug-vehicle administration were evaluated using the microdialysis technique. Results: All drugs and all doses significantly attenuated the spatial memory retention also decreased the rigidity and improved the locomotor activity of parkinsonian rats P 0.05. The microdialysis results showed the significant decrease in Striatal and CA1 hippocampus glutamatergic-cholinergic neurotransmission P 0.05 after administration of COX-2 and COX-2 gene expression inhibitors . The drugs had no significant effects on movement action of normal rats But they were able to attenuate the spatial memory retention and also only the high doses decreased the Striatal and CA1 hippocampus concentrations of glutamate and acetylcholine P 0.05. Conclusions: Our results confirm and suggest the more important role for Non steroidal and steroidal anti inflammatory drugs in treatment of the PD-movement disorders and also their effects on CA1 hippocampusstriatum glutamatergic-cholinergic neurotransmission in animal model of PD. Nonetheless these findings suggest that the chronic use of these agents will cause to spatial memory impairment in both of normal and parkinsonian rats and it is the awareness alarm for every neuroscientist that thinks these compounds may be useful in treatment of AD.