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P4‐292: Regional variations in age dependence of P‐gp‐mediated transport across the blood‐brain barrier measured using ( R )‐[ 11 C]verapamil and PET
Author(s) -
Berckel Bart N.M.,
Lubberink Mark,
Luurtsema Gert,
Boellaard Rol,
Lammertsma Adriaan
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2361
Subject(s) - verapamil , nuclear medicine , positron emission tomography , medicine , voxel , age groups , radiology , calcium , demography , sociology
found that astrocytic end-feet markers such as aquaporin-4 and Kir4.1 are reduced in models with vascular amyloid. These mice also had reduced astrocyte contact with the blood vessels in regions of vascular amyloid deposition. We examined brain perfusion in the APPSwDI and APPSwDI/ NOS2 mice and found significantly reduced brain perfusion in these CAA mice. Aquaporin-4 and Kir4.1 were also reduced in Alzheimer’s disease tissue with moderate and severe CAA deposition. Conclusions: Together, these data suggest a critical role for the neurovascular unit that contributes to the pathogenesis of Alzheimer’s disease.