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O1‐02–05: Automated longitudinal 3D mapping of hippocampal ADAS‐cog delayed recall effects in 293 normal elderly, MCI and Alzheimer's disease subjects
Author(s) -
Apostolova Liana G.,
Morra Jonathan H.,
Green Amity H.,
Hwang Kristy,
Avedissian Christina,
Parikshak Neelroop,
Cummings Jeffrey L.,
Toga Arthur W.,
Jack Clifford R.,
Weiner Michael W.,
Thompson Paul M.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.224
Subject(s) - subiculum , atrophy , hippocampal formation , dementia , alzheimer's disease , alzheimer's disease neuroimaging initiative , medicine , psychology , hippocampus , recall , biomarker , audiology , neuroscience , cardiology , disease , cognitive psychology , biology , dentate gyrus , biochemistry
patterns of subfield atrophy in AD and MCI. 2. To determine if subfield measurements provide advantages over total hippocampal volume for differentiation between groups. 3. To study the influence of ApoE4 on subfields in elderly controls and AD. Methods: 75 subjects (47 cognitively healthy elderly controls (mean age: 68.4 8.0), 14 MCI (mean age 75.3 6.5 and 14 AD (mean age70.4 8.2) were studied with a high resolution T2 weighted imaging sequence aimed at the hippocampus. Apo e4 carrier state was known in 11 AD (ApoE3/ApoE4: 3/8) and 38 controls (ApoE3/ApoE4: 29/14). Entorhinal cortex (ERC), subiculum, CA1, CA1-CA2 transition zone (CA1-2 transition), CA3-4& dentate gyrus (CA3&DG) and total hippocampal volume were manually marked. Statistical analysis was done with multiple regression and stepwise discriminant analysis. Results: Compared to controls, AD had significantly smaller volumes of ERC (-28.4%), subiculum (-23.0%), CA1 (-20.2%), CA1-2 transition (-31.4%) and total hippocampal volumes (-19.1%). MCI had smaller CA1 (-14%) and CA1-2 transition (26.1%) volumes. CA1-2 transition discriminated best between controls and MCI (Wilks’ Lambda 0.68, p 0.0001) and CA1-2 transition and ERC (Wilks’ Lambda 0.63, p 0.0001) between AD and control. ApoE4 exerted a negative effect on CA3&DG volumes in healthy controls (p 0.036) and in a mixed group of AD and controls (p 0.0003). In the latter group we also found a significant interaction between AD and ApoE4 (p 0.029). Conclusions: The patterns of subfield atrophy in AD and MCI were consistent with patterns of neuronal cell loss/ reduced synaptic density described in histopathologcal studies. ApoE4 effects were restricted to CA3&DG, i.e., the subfield capable of neurogenesis throughout adult life. These preliminary findings suggest that hippocampal subfield volumetry might be a better measure for diagnosis of early AD and for detection of other disease effects than measurement of total hippocampal volume.