Premium
P4‐139: Body fat composition and cognitive dysfunction in the elderly Korean
Author(s) -
Park Moon Ho,
Kim Nan-Hee,
Seo Ji-A.,
Han Changsu,
Kim Byong Kwon,
Jo Inho,
Jo Sangmee Ahn
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2205
Subject(s) - quartile , medicine , dementia , body mass index , prospective cohort study , obesity , cognition , population , abdominal obesity , metabolic syndrome , confidence interval , psychiatry , environmental health , disease
Background: In addition to the association between obesity and cardiovascular disorders, with the presence of a vascular burden as a cofactor, recent studies have particularly focused on the association between indicators of obesity and dementia. A high BMI can increase the risk for dementia when measured before clinical dementia onset. Although the use of BMI in population-based and clinical studies is feasible, this is an index of obesity and shows limits in its ability to distinguish between fat and fat-free mass or between visceral and subcutaneous abdominal fat. Methods: Subjects were followed up for about 2 years; 433 persons had BMI data and body fat distribution data by abdominal fat CT analysis. Cognitive function was ascertained using standard methods including K-MMSE and CERAD-K. Cognitive dysfunction was analyzed using follow-up as time to event, adjusting for demographics and apolipoprotein E-epsilon4 status. Results: Compared with subjects in the first quartile of initial BMI, subjects in the third quartile had a lower cognitive dysfunction. For total abdominal fat amount, subjects in the second quartile had a lower cognitive dysfunction. The association between adiposity and cognitive dysfunction resembled a U shape in the elderly Korean. Conclusions: The prospective association between adiposity and cognitive dysfunction differs depending on the body fat distribution. This may explain previous conflicting reports. Larger prospective studies are required to investigate this further.