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P4‐118: Impairment in gait is associated with prevalent mild cognitive impairment
Author(s) -
Roberts Rosebud O.,
Hollman John H.,
Geda Yonas E.,
Knopman David S.,
Cha Ruth H.,
Pankratz V. Shane,
Rocca Walter A.,
Petersen Ronald
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2184
Subject(s) - gait , quartile , dementia , physical medicine and rehabilitation , cognitive impairment , confidence interval , medicine , odds ratio , population , neuropsychology , stride , clinical dementia rating , cognition , physical therapy , psychology , psychiatry , disease , environmental health
increased risk of dementia, after adjustment for socioeconomic characteristics. The relative risk (RR) of aMCI and CIND did not change substantially after adjustment for other covariates, including ApoE4, vascular disease, polypharmacy, psychotropic drug use, low mood at time of outcome diagnosis, whereas the RRs for dementia decreased substantially. In all models, the RR for aMCI in relation to previously reported low mood was more than double the RR of OCIND and dementia. Further, marginally significant interaction was found between previously reported low mood and ApoE4 allele, in relation to the development of aMCI (Attributable Proportion: 0.6, 95% CI: 0.2-1.0). Conclusions: Special attention should be paid to depressive symptoms in cognitively intact elderly persons, as low mood appears to be strongly associated to incipient cognitive deterioration, especially of amnestic type, suggesting a possible common pathogenetic mechanism (e.g., volume losses in the medial-temporal lobe).