Premium
O1‐01–07: Frequency and clinical correlates of parkinsonism in the community‐dwelling elderly: The Mayo Clinic study of aging
Author(s) -
Boeve Bradley F.,
Molano Jennifer R.,
Mihci Ebru,
Roberts Rosebud O.,
Geda Yonas E.,
Knopman David S.,
Tangalos Eric G.,
Smith Glenn E.,
Ivnik Robert J.,
Cha Ruth,
Pankratz V. Shane,
Petersen Ronald C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.217
Subject(s) - parkinsonism , dementia , movement disorders , cohort , rating scale , medicine , postural tremor , psychology , cognitive impairment , physical therapy , pediatrics , physical medicine and rehabilitation , essential tremor , cognition , disease , psychiatry , developmental psychology
Background: There is a growing interest in the frequency and clinical correlates of parkinsonism in elderly community-dwelling subjects, but little data on these issues exist, particularly in a population-based sample. Methods: Subjects were 70-89 year old residents of Olmsted County, Minnesota, and underwent longitudinal assessments using standardized functional, sleep, clinical, neuropsychologic, and neuropsychiatric measures. Subjects were classified as cognitively normal (CN), or as having mild cognitive impairment (MCI) or dementia (Dem) based on published criteria. The motor subtest of the Unified Parkinson’s Disease Rating Scale (UPDRS) was completed on all subjects, and findings on each of the cardinal signs of parkinsonism (postural instability, bradykinesia, tremor, or rigidity) were recorded. Results: Out of the 2028 subjects in the entire cohort, 985 (49%) had parkinsonism, and 729 (36%) had postural instability, 436 (21%) had bradykinesia, 434 (21%) had tremor [185 (9%) with rest tremor], and 277 (14%) had rigidity at the baseline evaluation. The frequency of parkinsonism varied by age; 397 (20%) subjects in the 70-79 age range and 588 (29%) subjects in the 80-89 age range had parkinsonism. The frequency of parkinsonism also varied by sex; 547 (27%) male subjects and 438 (22%) female subjects had parkinsonism. Parkinsonism was present in 44% of those classified as CN, 63% with MCI, and 88% with Dem. Parkinsonism was associated with age 80-89 vs. 70-79 (OR 2.67, 95% CI 2.21, 3.21); male gender (OR 1.52, 95% CI 1.26, 1.83); and cognitive impairment vs. cognitive normal (OR 1.74, 95% CI 1.35, 2.24 for MCI; OR 7.16, 95% CI 3.35, 15.30 for dementia) after adjustment for age, sex, and education. Conclusions: Parkinsonism is common in the community-dwelling elderly, and is associated with increasing age, male gender, and increasing degree of cognitive impairment. Study supported by: U01 AG06786, P50 AG16574, RO1 AG15866, Robert H. and Clarice Smith and Abigail VanBuren Alzheimer s Disease Research Program.