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P4‐088: Community‐based prevalence of structural brain changes in dementia and cognitively impaired nondemented elderly from Brazil
Author(s) -
Lopes Marcos A.,
Litvoc Julio,
Furtado Erikson F.,
Santos Antonio C.,
Bottino Cássio M.C.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2153
Subject(s) - dementia , vascular dementia , medicine , stroke (engine) , atrophy , cognitive decline , gerontology , depression (economics) , disease , psychiatry , mechanical engineering , engineering , economics , macroeconomics
epitopes: LPS, major OMP, and purified elementary bodies. Results: Chlamydia-specific labeling was noted, in the brains of AR-39 infected mice, and was most prominent at 1 month p.i., which was prior to substantial amyloid deposition. Amyloid-specific labeling was prominent at and after 2 months p.i., but did not consistently co-localize with Chlamydia antigen. Conclusions: Our initial data suggest that Chlamydia infection, although initially established in the brains of BALB/c mice is limited with regards to co-localizing with resultant pathology, however, the infection may continue to serve as a chronic stimulus for inflammation in the brain that ultimately results in amyloid deposition.