P4‐088: Community‐based prevalence of structural brain changes in dementia and cognitively impaired nondemented elderly from Brazil

epitopes: LPS, major OMP, and purified elementary bodies. Results: Chlamydia-specific labeling was noted, in the brains of AR-39 infected mice, and was most prominent at 1 month p.i., which was prior to substantial amyloid deposition. Amyloid-specific labeling was prominent at and after 2 months p.i., but did not consistently co-localize with Chlamydia antigen. Conclusions: Our initial data suggest that Chlamydia infection, although initially established in the brains of BALB/c mice is limited with regards to co-localizing with resultant pathology, however, the infection may continue to serve as a chronic stimulus for inflammation in the brain that ultimately results in amyloid deposition.