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O1‐01–05: Memory performance is specifically related to amyloid and Tau pathology in the entorhinal cortex and hippocampus
Author(s) -
Reitz Christiane,
Honig Lawrence,
Vonsattel Jean Paul,
Tang Ming Xin,
Mayeux Richard
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.215
Subject(s) - subiculum , entorhinal cortex , hippocampal formation , hippocampus , neuroscience , temporal lobe , pathology , senile plaques , psychology , amyloid (mycology) , alzheimer's disease , medicine , disease , dentate gyrus , epilepsy
out based on accepted criteria, using immunohistochemistry for tau, beta-amyloid and alpha-synuclein proteins (and also for other proteins when necessary). Protocols are approved by the local ethics committee and a written informed consent form is obtained. Results: According to the CERAD criteria, 43 cases (52.4%) were diagnosed as AD (19 definite, 15 probable and 9 possible AD). Eleven of these cases also had vascular changes and five cases had concomitant argyrophilic grain disease . The most prevalent non-AD causes of dementia were: vascular (16 cases), argyrophilic grain disease (7 cases) and Lewy body dementia/Parkinson disease complex (4 cases). Conclusions: Neuropathologically confirmed AD was the most frequent cause of dementia. In addition, vascular changes, a preventable cause of cognitive decline, are very prevalent in this Brazilian sample.