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P4‐074: MRI brain aging markers—interrelationships and correlates: The three‐city study—
Author(s) -
Godin Ophelia,
Dufouil Carole,
Maillard Pauline,
Crivello Fabrice,
Alperovitch Annick,
Mazoyer Bernard,
Tzourio Christophe
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2139
Subject(s) - atrophy , brain size , voxel based morphometry , medicine , white matter , voxel , hippocampal formation , grey matter , hyperintensity , population , confounding , cardiology , pathology , magnetic resonance imaging , radiology , environmental health
glucose homeostasis (IPGTT) is observed but this happens only at early stages of the disease when only intraneuronal AB is reported in these animals. Conclusions: These results reinforce the probable contribution of intraneuronal occurrence of AB in the modification of neurophysiological homeostasis. Further studies should be carried out to elucidate the disruption of glucose homeostasis at the appearance of intraneuronal AB and how this relates to the progression of the disease.