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P4‐068: Inflammatory markers are associated with cognitive domains other than memory in a non‐demented elderly cohort: Results from the Einstein Aging Study (EAS)
Author(s) -
Derby Carol A.,
Katz Mindy J.,
Zimmerman Molly,
Sanders Amy E.,
Verghese Joe,
Lipton Richard B.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2133
Subject(s) - episodic memory , population , verbal fluency test , dementia , medicine , cognitive decline , cognition , psychology , trail making test , cohort , logical address , inflammation , verbal memory , neuropsychology , disease , psychiatry , environmental health , physical address , computer science , programming language , overlay
18% respectively in this country. In the absence of definitive treatment, strategies to delay onset or reduce risk for dementia would be greatly beneficial. This long-term study has been designed to determine whether cardiovascular disease risk factors are associated with an increased risk for dementia and AD in Sri Lanka. Methods: This prospective cognitive sub-study is being conducted as part of a large, community-based epidemiological study being conducted in Ragama, Sri Lanka, to establish diagnostic criteria for metabolic syndrome (Ragama Health Study). 2470 adults 45-65 years of age identified by a stratified random sampling technique underwent detailed lifestyle and significant event history, physical examination, cognitive assessment with MMSE, and biochemical analysis of blood. Of this, 496 subjects who had a MMSE score of 21 (maximum 30), were recruited for long-term follow up. Results: Baseline data for the 496 subjects (males 42.3%) are reported here [mean (range)]; age 55.3 (45-65) yrs, MMSE 18 (0-21), BMI 24.2 (15.5-35.6), systolic BP 138.2 (88-238) mmHg, fasting blood sugar 117.4 (65-473) mg/dl, serum cholesterol 216.5 (112-381) mg/dl, serum triglycerides 130.9 (36-428) mg/dl, and serum insulin 8.7 (0.6-61) u/ml. Systolic BP and serum cholesterol were higher in this group. Conclusions: This cohort will be followed up prospectively with detailed cognitive assessments, blood analyses, and brain imaging annually. The ultimate aim of this study is to reduce dementia burden by identifying modifiable risk factors in order to introduce appropriate interventions.