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P4‐051: Alzheimer's disease risk in relation to nutrition and physical activity
Author(s) -
Scarmeas Nikos,
Schupf Nicole,
Stern Yaakov,
Luchsinger Jose
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2116
Subject(s) - medicine , cohort , body mass index , proportional hazards model , mediterranean diet , logistic regression , comorbidity , gerontology , cohort study , demography , sociology
of these associations will be discussed We review literature suggesting that neurological damage precipitated by depression and the increased risk for neuronal death associated with the APOE 4 allele together lower cognitive reserve. That is, strategies the individual may use to compensate for initial losses are undermined by this dual assault on the brain. Finally, we discuss the influence of racial disparities in cognitive functioning in the context of differences in socioeconomic status. Specifically, education and literacy may be protective against CD. Early educational disadvantages experienced by African Americans may explain increased rates of CD in African Americans.