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P4‐048: Pulse pressure, dementia and Alzheimer's disease: The Oxford Project to Investigate Memory and Ageing (OPTIMA) Longitudinal Study
Author(s) -
Razay George,
Williams Jonathon,
King Elizabeth,
Smith A. David,
Wilcock Gordon
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2112
Subject(s) - dementia , pulse pressure , medicine , cohort , ageing , cardiology , blood pressure , cognitive decline , longitudinal study , alzheimer's disease , prospective cohort study , diastole , gerontology , cognition , psychology , disease , psychiatry , pathology
went telephonic cognitive assessment by the Modified Telephone Interview for Cognitive Status. Subjects identified as possibly demented were interviewed face-to-face. Tendency for rumination in familial and work setting ranged between “1” always forget, “2” tend to forget, “3‘tend to ruminate, “4” usually ruminate. Results: Of 1,892 subject assessed for dementia (mean age 82 at assessment), 309 were diagnosed as demented, 175 as suffering from cognitive impairment not sufficient for the diagnosis of dementia and 1,408 had no cognitive impairment. The prevalence rates of dementia (and odds ratios relative to those with least tendency for rumination, adjusted for age, area of birth, and socioeconomic status) were 21% for group “1‘, with the lowest rumination score, 18%, 14% and 14% for groups “2‘, “3” and “4” in groups of rumination in familial settings respectively and 24%, 19%, 15% and 15% for groups “1” through “4” respectively of tendency for rumination in work settings. In both settings, estimated OR for dementia decreased by 0.19 0.20 for each rise in rumination score. Conclusions: Examining psychologicalcognitive style when confronting distress might shed light into personality characteristics that increase the risk for dementia. Mechanisms underlying these associations remain elusive.