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P4‐009: Transitioning forward to CDR 0.5 and 1+ versus backward from CDR 0.5 to 0: Are the risk factors the same? The Kame Project
Author(s) -
Borenstein Amy R.,
Schofield Elizabeth,
Wu Yougui,
Schellenberg Gerard D.,
Bowen James,
McCormick Wayne,
Larson Eric B.
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.2073
Subject(s) - business
Conclusions: Our results suggest that FHx of AD has a stronger association with microstructural brain differences, than 4. Presence of 4 alone was not associated with measurable difference, though presence of FHx and 4 resulted in the greatest difference in FA. These results support the conclusion that a greater emphasis be placed on elucidating the contribution of FHx to early brain changes in people at risk for AD. Additionally, our results provide evidence that DTI may be useful for detecting or tracking AD related brain changes, prior to disease onset.