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P3‐292: Association of apolipoprotein E and serum abeta levels in men undergoing intermittent androgen ablation
Author(s) -
Cherrier Monique,
Green Patti,
Schellenberg Gerald,
Higano Celestia
Publication year - 2008
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2008.05.1860
Subject(s) - medicine , testosterone (patch) , apolipoprotein e , endocrinology , prostate cancer , androgen , androgen deprivation therapy , flutamide , hormone , disease , cancer , androgen receptor
1 week) with the accumulation of intraneuronal apoE in these neurons. Furthermore, these effects are associated with the loss of CA1 neurons synapses and with the occurrence of pronounced learning and memory deficits. Conclusions: These findings provide the first in vivo evidence regarding the cellular mechanisms underlying the pathological cross talk between apoE4 and A , as well as a novel model system of neurodegeneration in vivo that is uniquely suitable for studying the early stages of the amyloid cascade and the effects thereon of apoE4.